eIF1AD is a 165 amino acid protein that belongs to the eIF1AD family and contains one S1-like domain. eIF1AD localizes to nucleus and is expressed in the glioblastoma cell line U-87 MG, the embryonic kidney cell line HEK-293, the pancreatic carcinoma cell line PANSLC1, the breast carcinoma cell line MCF7, the lung cancer cell line NCI-H92, and the chronic myelogenous leukemia cell line K-562. eIF1AD interacts with GAPDH and may function to reduce cell proliferation. The gene encoding eIF1AD maps to human chromosome 11q13.1. With approximately 135 million base pairs and 1,400 genes, chromosome 11 makes up around 4% of human genomic DNA and is considered a gene and disease association dense chromosome. Jervell and Lange-Nielsen syndrome, Jacobsen syndrome, Niemann-Pick disease, hereditary angioedema and Smith-Lemli-Opitz syndrome are associated with defects in chromosome 11.
Function:
Plays a role into cellular response to oxidative stress. Decreases cell proliferation.
Subunit:
Interacts with GAPDH and STAT1.
Subcellular Location:
Nucleus.
Tissue Specificity:
Expressed in the glioblastoma cell line U-87MG, the embryonic kidney cell line HEK-293, the pancreatic carcinoma cell line PANSLC1, the breast carcinoma cell line MCF-7, the lung cancer cell line NCI-H92, and the chronic myelogenous leukemia cell line K-562.
Similarity:
Belongs to the EIF1AD family.
Contains 1 S1-like domain.
SWISS:
Q8N9N8
Gene ID:
84285
Database links:
Entrez Gene: 84285 Human
Entrez Gene: 615726 Cow
Entrez Gene: 69860 Mouse
Entrez Gene: 293673 Rat
SwissProt: Q58CY2 Cow
SwissProt: Q4R354 Cynomolgus Monkey
SwissProt: Q8N9N8 Human
SwissProt: Q3THJ3 Mouse
SwissProt: Q5RKI6 Rat
Unigene: 425178 Human
Unigene: 299167 Mouse
Unigene: 4163 Rat
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