The protein encoded by this gene is the largest subunit of a heterotrimeric GTP-binding protein involved in the recruitment of methionyl-tRNA(i) to the 40 S ribosomal subunit. [provided by RefSeq, Jan 2010]
Function:
eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B
Subunit:
Heterotrimer composed of an alpha, a beta and a gamma chain.
Similarity:
Belongs to the GTP-binding elongation factor family. EIF2G subfamily.
SWISS:
P41091
Gene ID:
1968
Database links:
Entrez Gene: 1968 Human
Entrez Gene: 26905 Mouse
Entrez Gene: 26908 Mouse
Entrez Gene: 100312984 Rat
Entrez Gene: 299027 Rat
Omim: 300161 Human
SwissProt: P41091 Human
SwissProt: Q9Z0N1 Mouse
SwissProt: P81795 Rat
Unigene: 539684 Human
Unigene: 218851 Mouse
Unigene: 250909 Mouse
Unigene: 220237 Rat
Unigene: 87025 Rat
|
|
