mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. Functions as a regulator of apoptosis. Mediates effects of polyamines on neuronal process extension and survival. May play an important role in brain development and function, and in skeletal muscle stem cell differentiation.
Subcellular Location:
Cytoplasm. Nucleus. Endoplasmic reticulum membrane. Nucleus > nuclear pore complex. Hypusine modification promotes the nuclear export and cytoplasmic localization and there was a dynamic shift in the localization from predominantly cytoplasmic to primarily nuclear under apoptotic inducing conditions.
Tissue Specificity:
Expressed in ovarian and colorectal cancer cell lines (at protein level). Highly expressed in testis. Overexpressed in some cancer cells.
Post-translational modifications:
eIF-5A seems to be the only eukaryotic protein to have an hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group (from spermidine).
Similarity:
Belongs to the eIF-5A family.
SWISS:
Q9GZV4
Gene ID:
56648
Database links:
Entrez Gene: 56648 Human
Entrez Gene: 208691 Mouse
Entrez Gene: 310261 Rat
Omim: 605782 Human
SwissProt: Q9GZV4 Human
SwissProt: Q8BGY2 Mouse
Unigene: 164144 Human
Unigene: 193670 Mouse
Unigene: 47334 Rat
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