The protein encoded by this gene is a member of the ETS-domain transcription factor family and the ternary complex factor (TCF) subfamily. Proteins in this subfamily regulate transcription when recruited by serum response factor to bind to serum response elements. This protein is activated by signal-induced phosphorylation; studies in rodents suggest that it is a transcriptional inhibitor in the absence of Ras, but activates transcription when Ras is present. [provided by RefSeq, Jul 2008]
Function:
May be a negative regulator of transcription, but can activate transcription when coexpressed with Ras, Src or Mos. Forms a ternary complex with the serum response factor and the ETS and SRF motifs of the Fos serum response element.
Subunit:
Interacts with CTBP1.
Subcellular Location:
Nucleus.
Similarity:
Belongs to the ETS family.
Contains 1 ETS DNA-binding domain.
SWISS:
P41970
Gene ID:
2004
Database links:
Entrez Gene: 2004 Human
Entrez Gene: 417919 Chicken
Entrez Gene: 541125 Cow
Entrez Gene: 482613 Dog
Entrez Gene: 13713 Mouse
Entrez Gene: 362871 Rat
Omim: 600247 Human
SwissProt: P41970 Human
SwissProt: P41971 Mouse
Unigene: 46523 Human
Unigene: 4454 Mouse
Unigene: 196088 Rat
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