This gene encodes a novel neural/endocrine-specific cytosolic and peripheral membrane protein required for the Ca2+-regulated exocytosis of secretory vesicles. The protein acts at a stage in exocytosis that follows ATP-dependent priming, which involves the essential synthesis of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Alternative splicing has been observed at this locus and three variants, encoding distinct isoforms, are described. [provided by RefSeq, Aug 2008]
Function:
CAPS/Cadps family which consists of two members, CAPS1 and CAPS2. The CAPS family proteins are involved in the secretion of different secretory substances in developing and postnatal brains. In addition CAPS1 regulates catecholamine release from neuroendocrine cells and is expressed predominantly in the brain.
Subunit:
Homodimer. Interacts with RASL10B. Interacts with the dopamine receptor DRD2.
Subcellular Location:
Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction, synapse. Note=Membrane-associated to vesicles. Strongly enriched in synaptic fractions. Preferentially binds to DCVs but not to SVs. Binds phosphoinosides, with a strong selectivity for PtdIns(4,5)P2 over PtdIns(3,4,5)P3. Probably localizes to different vesicles compared to CADPS2.
Tissue Specificity:
Specifically expressed in neural and endocrine secretory tissues. Expressed in brain and pancreas and at low level in heart. Also expressed in fetal heart, cerebellum, cerebral cortex, medulla, occipital pole, frontal and temporal lobes, and putamen, as well as weak expression in spinal cord.
Similarity:
Contains 1 C2 domain.
Contains 1 MHD1 (MUNC13 homology domain 1) domain.
Contains 1 PH domain.
SWISS:
Q9ULU8
Gene ID:
8618
Database links:
Entrez Gene: 8618 Human
Entrez Gene: 27062 Mouse
Entrez Gene: 26989 Rat
Omim: 604667 Human
SwissProt: Q9ULU8 Human
SwissProt: Q80TJ1 Mouse
SwissProt: Q62717 Rat
Unigene: 260881 Mouse
Unigene: 88197 Rat
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