Rabbit Anti-phospho-STK25 (Thr174) antibody

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STK25 (phospho T174); p-STK25 (phospho T174); Serine/threonine kinase 25; Serine/threonine kinase 25 (STE20 homolog, yeast); Serine/threonine kinase 25 (STE20 homolog, yeast), isoform CRA_a; Serine/threonine kinase 25 (yeast); Serine/threonine protein kin

Cat:

SL10683R

Species Reactivity：

(predicted: Human,Mouse,Rat,Cow,Horse,Sheep,)

Immunogen：

KLH conjugated synthesised phosphopeptide derived from human STK25 around the phosphorylation site of Thr174:RN(p-T)FV

Format：

Liquid

Storage instructions：

Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

WB=1:500-2000ELISA=1:5000-10000IHC-P=1:100-500IHC-F=1:100-500ICC=1:100-500IF=1:100-500（Paraffin sections need to do antigen repair）not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

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Unit:

Price: $228.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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Oxidant stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Targets to the Golgi apparatus where it appears to regulate protein transport events, cell adhesion, and polarity complexes important for cell migration.
Several mammalian kinases have been identified which exhibit sequence similarity to the Saccharomyces cerevisiae serine/threonine kinase STE20. STE20 is involved in relaying signals from G-protein coupled receptors, and it lies upstream of a MAP kinase kinase kinase. Mammalian STE20-like kinases include YSK1, KHS, GLK, NIK, HPK1, Krs-1, Krs-2 and GC kinase. YSK1 (yeast SPS/STE20-related kinase 1) is expressed in a wide variety of cell types and tissues and has been shown to have kinase activity. Unlike many of the other STE20-like kinases, however, overexpression of YSK1 does not lead to activation of the SAPK/JNK pathway.

Function:
Oxidant stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Targets to the Golgi apparatus where it appears to regulate protein transport events, cell adhesion, and polarity complexes important for cell migration.

Subunit:
Homodimer.

Subcellular Location:
Cytoplasm. Golgi apparatus. Localizes to the Golgi apparatus.

Tissue Specificity:
Ubiquitously expressed. Highest levels are found in testis, large intestine, brain and stomach followed by heart and lung.

Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR.

Similarity:
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
Contains 1 protein kinase domain.

SWISS:
O00506

Gene ID:
10494

Database links:

Entrez Gene: 10494 Human

Entrez Gene: 51765 Human

Entrez Gene: 8428 Human

Omim: 300547 Human

Omim: 602255 Human

Omim: 604984 Human

SwissProt: O00506 Human

SwissProt: Q9P289 Human

SwissProt: Q9Y6E0 Human

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