This gene encodes an endo/exonuclease with 5'-3' exonuclease activity. The encoded enzyme catalyzes the hydrolysis of ester linkages at the 5' end of a nucleic acid chain. This enzyme is localized to the mitochondria and may play a role in programmed cell death. Alternatively spliced transcript variants have been described. A pseudogene exists on chromosome 18. [provided by RefSeq, Feb 2009]
Function:
Endo/exonuclease with nicking activity towards supercoiled DNA, a preference for single stranded DNA and 5'-3' exonuclease activity.
Subcellular Location:
Mitochondrion inner membrane.
Tissue Specificity:
Ubiquitous.
Similarity:
Belongs to the DNA/RNA non-specific endonuclease family.
SWISS:
Q9Y2C4
Gene ID:
9941
Database links:
Entrez Gene: 9941 Human
Entrez Gene: 208194 Mouse
Entrez Gene: 301062 Rat
Omim: 604051 Human
SwissProt: Q9Y2C4 Human
SwissProt: Q8C163 Mouse
Unigene: 517897 Human
Unigene: 101578 Mouse
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