This gene is a tumor-specific member of the ECTO-NOX family of genes that encode cell surface NADH oxidases. The encoded protein has two enzymatic activities: catalysis of hydroquinone or NADH oxidation, and protein disulfide interchange. The protein also displays prion-like properties. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Function:
Probably acts as a terminal oxidase of plasma electron transport from cytosolic NAD(P)H via hydroquinones to acceptors at the cell surface. Hydroquinone oxidase activity alternates with a protein disulfide-thiol interchange/oxidoreductase activity which may control physical membrane displacements associated with vesicle budding or cell enlargement. The activities oscillate with a period length of 24 minutes and play a role in control of the ultradian cellular biological clock.
Subcellular Location:
Cell membrane. Secreted; extracellular space. Extracellular and plasma membrane-associated.
Tissue Specificity:
Expressed in lymphocyte cells, breast and breast cancer (at protein level). Found in the sera of cancer patients with a wide variety of cancers including breast, prostate, lung and ovarian cancers, leukemias, and lymphomas. Found also in the serum of healthy volunteers or patients with disorders other than cancer. Probably shed into serum by cancer cells.
Similarity:
Belongs to the ENOX family.
Contains 1 RRM (RNA recognition motif) domain.
SWISS:
Q8TC92
Gene ID:
55068
Database links:
Entrez Gene: 10495 Human
Entrez Gene: 55068 Human
Entrez Gene: 209224 Mouse
Entrez Gene: 239188 Mouse
Entrez Gene: 306038 Rat
Omim: 610914 Human
SwissProt: Q16206 Human
SwissProt: Q8TC92 Human
SwissProt: Q8SHR2 Mouse
SwissProt: Q8R0Z2 Mouse
Unigene: 128258 Human
Unigene: 171458 Human
Unigene: 327730 Mouse
Unigene: 441158 Mouse
Unigene: 98096 Mouse
Unigene: 212211 Rat
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