Rabbit Anti-ENTPD4 antibody

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Apyrase lysosomal; Ectonucleoside triphosphate diphosphohydrolase 4; ENTPD 4; Golgi luminal UDPase; Guanosine diphosphatase like protein; KIAA0392; LALP70; ENTP4_HUMAN; LAP70; LYSAL1; Lysosomal apyrase like 1; Lysosomal apyrase like protein of 7

Cat:

SL1921R

Species Reactivity：

(predicted: Human,Mouse,Rat,Dog,Pig,Cow,Horse,)

Immunogen：

KLH conjugated synthetic peptide derived from human ENTPD4:101-200/616

Format：

Liquid

Storage instructions：

Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

IHC-P=1:100-500IHC-F=1:100-500ICC=1:100-500IF=1:100-500（Paraffin sections need to do antigen repair）not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

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Unit:

Price: $228.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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This gene encodes a member of the apyrase protein family. Apyrases are enzymes that catalyze the hydrolysis of nucleotide diphosphates and triphosphates in a calcium or magnesium-dependent manner. The encoded protein is an endo-apyrase and may play a role in salvaging nucleotides from lysosomes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and these isoforms may differ in divalent cation dependence and substrate specificity. [provided by RefSeq, Sep 2011]

Function:
ENTPD4 (Ectonucleoside triphosphate diphosphohydrolase 4) preferentially hydrolyzes nucleoside 5'-diphosphates. Nucleoside 5'-triphosphates are hydrolyzed only to a minor extent. The order of activity with different substrates is UDP >> GDP = CDP = TDP. AMP, ADP, ATP and UMP are not substrates. There are two named isoforms. The preferred substrates for isoform 2 are CTP, UDP, CDP, GTP and GDP, while isoform 1 utilizes UTP and TTP.

Subcellular Location:
Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle, autophagosome membrane; Multi-pass membrane protein. Note: Localizes in the Golgi and autophagic vacuoles/lysosomes.

Tissue Specificity:
Ubiquitous. Highest expression in testis and lowest in bladder.

Similarity:
Belongs to the GDA1/CD39 NTPase family.

SWISS:
Q9Y227

Gene ID:
9583

Database links:

Entrez Gene: 9583 Human

Entrez Gene: 67464 Mouse

Entrez Gene: 361063 Rat

Omim: 607577 Human

SwissProt: Q9Y227 Human

SwissProt: Q9DBT4 Mouse

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