ZNF445 is highly expressed in adult skeletal muscle and testis, while expressed at lower levels in small intestine, pancreas, colon, thymus, uterus and peripheral blood leukocytes. Overexpression of ZNF445 results in the activation of c-Jun and serum response element, suggesting a potential role in the MAPK signaling pathway.
Function:
May be involved in transcriptional regulation.
Subcellular Location:
Nucleus.
Similarity:
Belongs to the krueppel C2H2-type zinc-finger protein family.
Contains 14 C2H2-type zinc fingers.
Contains 1 KRAB domain.
Contains 1 SCAN box domain.
SWISS:
P59923
Gene ID:
353274
Database links:
Entrez Gene: 353274 Human
Entrez Gene: 235682 Mouse
SwissProt: P59923 Human
SwissProt: Q8R2V3 Mouse
Unigene: 250481 Human
Unigene: 326477 Mouse
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