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Rabbit Anti-Ephrin A4 antibody
This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNA class ephrin. Three transcript variants that encode distinct proteins have been identified. [provided by RefSeq, Jul 2008]
Function:
Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. May play a role in the interaction between activated B-lymphocytes and dendritic cells in tonsils.
Subcellular Location:
Isoform 1: Cell membrane; Lipid-anchor, GPI-anchor.
Isoform 2: Secreted (Probable).
Tissue Specificity:
Expressed in the adult spleen, lymph node, prostate, ovary, small intestine, and colon, and in fetal heart, lung, liver and kidney. Also detected in hematopoietic cell lines.
Similarity:
Belongs to the ephrin family.
Contains 1 ephrin RBD (ephrin receptor-binding) domain.
SWISS:
P52798
Gene ID:
1945
Database links:
Entrez Gene: 1945 Human
Entrez Gene: 13639 Mouse
Omim: 60276 Human
SwissProt: P52798 Human
SwissProt: O08542 Mouse
SwissProt: Q3UQB5 Mouse
SwissProt: Q9CZS8 Mouse
Unigene: 449913 Human
Unigene: 639422 Human
Unigene: 16332 Mouse
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