Rabbit Anti-Epoxide hydrolase 1 antibody

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EPHX 1; EPHX; EPHX1; EPOX; Epoxide hydratase; Epoxide hydrolase 1; Epoxide hydrolase 1 microsomal (xenobiotic); Epoxide hydroxylase 1; Epoxide hydroxylase 1 microsomal (xenobiotic); HYEP_HUMAN; HYL1; mEH; Microsomal epoxide hydrolase.

Cat:

SL14614R

Species Reactivity：

(predicted: Human,Mouse,Rat,Pig,Cow,Horse,Rabbit,Sheep,)

Immunogen：

KLH conjugated synthetic peptide derived from human Epoxide hydrolase 1:21-120/455

Format：

Liquid

Storage instructions：

Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

IHC-P=1:100-500IHC-F=1:100-500ICC=1:100-500IF=1:100-500（Paraffin sections need to do antigen repair）not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

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Unit:

Price: $228.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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Epoxide hydrolase is a critical biotransformation enzyme that converts epoxides from the degradation of aromatic compounds to trans-dihydrodiols which can be conjugated and excreted from the body. Epoxide hydrolase functions in both the activation and detoxification of epoxides. Mutations in this gene cause preeclampsia, epoxide hydrolase deficiency or increased epoxide hydrolase activity. Alternatively spliced transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Dec 2008]

Function:
Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water.

Subcellular Location:
Microsome membrane. Endoplasmic reticulum membrane.

Tissue Specificity:
Found in liver.

DISEASE:
Note=In some populations, the high activity haplotype tyr113/his139 is overrepresented among women suffering from pregnancy-induced hypertension (pre-eclampsia) when compared with healthy controls.
Defects in EPHX1 are a cause of familial hypercholanemia (FHCA) [MIM:607748]. FHCA is a disorder characterized by elevated serum bile acid concentrations, itching, and fat malabsorption.

Similarity:
Belongs to the peptidase S33 family.

SWISS:
P07099

Gene ID:
2052

Database links:

Entrez Gene: 2052 Human

Entrez Gene: 535293 Cow

Entrez Gene: 13849 Mouse

Entrez Gene: 397639 Pig

Entrez Gene: 25315 Rat

Omim: 132810 Human

SwissProt: P07099 Human

SwissProt: Q9D379 Mouse

SwissProt: P79381 Pig

SwissProt: P07687 Rat

Unigene: 89649 Human

Unigene: 9075 Mouse

Unigene: 723 Rat

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