This gene encodes a GTPase that belongs to the GTP-binding elongation factor family. The encoded protein is a polypeptide release factor that complexes with eukaryotic peptide chain release factor 1 to mediate translation termination. This protein may also be involved in mRNA stability.[provided by RefSeq, Mar 2010]
Function:
Involved in translation termination in response to the termination codons UAA, UAG and UGA. May play a role as a potent stimulator of the release factor activity of ETF1. Exhibits GTPase activity, which is ribosome- and ETF1-dependent. May play a role in cell cycle progression. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons.
Subunit:
Interacts with ETF1 (By similarity). Component of the transient SURF (SMG1-UPF1-eRF1-eRF3) complex. Interacts with UPF1 and PABPC1.
Subcellular Location:
Cytoplasm.
Tissue Specificity:
Highly expressed in IUCC stage II colorectal cancer (CRC).
Similarity:
Belongs to the GTP-binding elongation factor family. ERF3 subfamily.
SWISS:
Q8IYD1
Gene ID:
23708
Database links:
Entrez Gene: 23708 Human
Entrez Gene: 14853 Mouse
Omim: 300418 Human
SwissProt: Q8IYD1 Human
SwissProt: Q149F3 Mouse
Unigene: 59523 Human
Unigene: 20826 Mouse
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