Rabbit Anti-ERLEC1 antibody

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C2orf30; CL24936; CL2508; endoplasmic reticulum lectin 1; ER lectin; erlectin 1; RP23 20N14.5; ERLEC_HUMAN; XTP3 B; XTP3 transactivated gene B protein; XTP3 transactivated protein B; XTP3B; XTP3TPB.

Cat:

SL14625R

Species Reactivity：

(predicted: Human,Mouse,Rat,Chicken,Dog,Pig,Cow,Horse,Rabbit,Sheep,)

Immunogen：

KLH conjugated synthetic peptide derived from human ERLEC1:391-483/483

Format：

Liquid

Storage instructions：

Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ELISA=1:5000-10000IHC-P=1:100-500IHC-F=1:100-500ICC=1:100-500IF=1:100-500（Paraffin sections need to do antigen repair）not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

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Unit:

Price: $228.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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This gene encodes a resident endoplasmic reticulum (ER) protein that functions in N-glycan recognition. This protein is thought to be involved in ER-associated degradation via its interaction with the membrane-associated ubiquitin ligase complex. It also functions as a regulator of multiple cellular stress-response pathways in a manner that promotes metastatic cell survival. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 21. [provided by RefSeq, Aug 2011]

Function:
ERLEC1 is a probable lectin that binds selectively to improperly folded lumenal proteins. ERLEC1 may function in endoplasmic reticulum quality control and endoplasmic reticulum-associated degradation (ERAD) of both non-glycosylated proteins and glycoproteins.

Subunit:
May form a complex with OS9, HSPA5, SYVN1, and SEL1L with which it interacts directly. Interacts (via PRKCSH 2 domain) with KREMEN2 (when glycosylated). Interacts with HSPA5.

Subcellular Location:
Endoplasmic reticulum lumen.

Post-translational modifications:
Isoform 1 and isoform 2 are N-glycosylated.

Similarity:
Contains 2 PRKCSH domains.

SWISS:
Q96DZ1

Gene ID:
27248

Database links:

Entrez Gene: 27248 Human

Omim: 611229 Human

SwissProt: Q96DZ1 Human

Unigene: 438336 Human

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