Rabbit Anti-KCNIP4 antibody

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A type potassium channel modulatory protein 4; a-type potassium channel modulatory protein 4; CALP; calsenilin like protein; Calsenilin-like protein; HGNC:30083; KCHIP 4; KCHIP4; KCIP4_HUMAN; KCNIP 4; Kcnip4; Kv channel interacting protein 4;

Cat:

SL14646R

Species Reactivity：

(predicted: Human,Mouse,Rat,Dog,Cow,)

Immunogen：

KLH conjugated synthetic peptide derived from human KCNIP4:41-140/250

Format：

Liquid

Storage instructions：

Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

WB=1:500-2000ELISA=1:5000-10000IHC-P=1:100-500IHC-F=1:100-500ICC=1:100-500IF=1:100-500（Paraffin sections need to do antigen repair）not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

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Unit:

Price: $228.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belong to the recoverin branch of the EF-hand superfamily. Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native Kv4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. This protein member also interacts with presenilin. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

Function:
Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Probably modulates channels density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. In vitro, modulates KCND2/Kv4.2 and KCND3/Kv4.3 currents.

Subcellular Location:
Cell membrane.

Tissue Specificity:
Predominantly expressed in brain.

Similarity:
Belongs to the recoverin family.
Contains 4 EF-hand domains.

SWISS:
Q6PIL6

Gene ID:
80333

Database links:

Entrez Gene: 614299 Cow

Entrez Gene: 80333 Human

Entrez Gene: 80334 Mouse

Entrez Gene: 259243 Rat

Omim: 608182 Human

SwissProt: Q2KI69 Cow

SwissProt: Q6PIL6 Human

SwissProt: Q6PHZ8 Mouse

SwissProt: Q99MG9 Rat

Unigene: 655705 Human

Unigene: 160172 Mouse

Unigene: 205864 Rat

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