ETV3 belongs to the ETS family of transcription factors and functions as a transcriptional repressor. ETS family members share a highly conserved DNA binding domain and play a role in growth factor pathways regulating proliferation and differentiation. PE-1 is ubiquitously expressed and localizes to the nucleus. Its expression can be induced by IL-10 via the STAT3 pathway suggesting that PE-1 contributes to the IL-10 downstream anti-inflammatory effects. During terminal cell differentiation, PE-1 plays a role in growth arrest by specifically repressing the target genes that are involved in Ras-dependent proliferation. The contributions of PE-1 to these anti-proliferative effects are heavily dependent on its interaction with Gemin3. Two PE-1 isoforms exist due to alternative splicing events.
Function:
Transcriptional repressor that contribute to growth arrest during terminal macrophage differentiation by repressing target genes involved in Ras-dependent proliferation. Represses MMP1 promoter activity.
Subcellular Location:
Nucleus.
Similarity:
Belongs to the ETS family.
Contains 1 ETS DNA-binding domain.
SWISS:
P41162
Gene ID:
2117
Database links:
Entrez Gene: 2117 Human
Entrez Gene: 27049 Mouse
Entrez Gene: 295297 Rat
Omim: 164873 Human
SwissProt: P41162 Human
SwissProt: Q8R4Z4 Mouse
Unigene: 105636 Human
Unigene: 21992 MouseUnigene: 225088
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