The protein encoded by this gene is a component of the exocyst complex. The exocyst complex plays a critical role in vesicular trafficking and the secretory pathway by targeting post-Golgi vesicles to the plasma membrane. The encoded protein is required for assembly of the exocyst complex and docking of the complex to the plasma membrane. The encoded protein may also play a role in pre-mRNA splicing through interactions with pre-mRNA-processing factor 19. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 4. [provided by RefSeq, Nov 2011]
Function:
Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. In adipocytes, plays a crucial role in targeting SLC2A4 vesicle to the plasma membrane in response to insulin, perhaps directing the vesicle to the precise site of fusion.
Subcellular Location:
Cytoplasm > cytosol. Cell membrane. Translocates, as a preformed complex with SEC6 and SEC8, to the plasma membrane in response to insulin through the activation of ARHQ.
Similarity:
Belongs to the EXO70 family.
SWISS:
Q9UPT5
Gene ID:
23265
Database links:
Entrez Gene: 23265 Human
Entrez Gene: 417361 Chicken
Entrez Gene: 505568 Cow
Entrez Gene: 53413 Mouse
Entrez Gene: 64632 Rat
Entrez Gene: 406723 Zebrafish
Omim: 608163 Human
SwissProt: Q5ZIN3 Chicken
SwissProt: Q3ZC43 Cow
SwissProt: Q9UPT5 Human
SwissProt: O35250 Mouse
SwissProt: O54922 Rat
SwissProt: Q7ZTX5 Zebrafish
Unigene: 514496 Human
Unigene: 533985 Human
Unigene: 22530 Mouse
Unigene: 45761 Rat
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