Rabbit Anti-EXOSC8 antibody

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bA421P11.3; CBP interacting protein 3; CIP3; EAP2; EC 3.1.13; exosome complex component RRP43; Exosome complex exonuclease RRP43; Exosome component 8; OIP2; EXOS8_HUMAN; Opa interacting protein 2; OTTHUMP00000042274; p9; Ribosomal RNA processi

Cat:

SL14670R

Species Reactivity：

(predicted: Human,Mouse,Rat,Dog,Horse,Rabbit,)

Immunogen：

KLH conjugated synthetic peptide derived from human EXOSC8:1-100/276

Format：

Liquid

Storage instructions：

Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ELISA=1:5000-10000IHC-P=1:100-500IHC-F=1:100-500ICC=1:100-500IF=1:100-500（Paraffin sections need to do antigen repair）not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

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Unit:

Price: $228.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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EXOSC8 (exosome component 8) is a component of the exosome 3'->5' exoribonuclease complex. This complex degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions. EXOSC8 is required for the 3' processing of the 7S pre-RNA to the mature 5.8S rRNA and also has a 3'-5' exonuclease activity.

Function:
Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may becinvolved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC8 binds to ARE-containing RNAs.

Subunit:
Component of the RNA exosome complex. Specifically part of the catalytically inactive RNA exosome core (Exo-9) complex which is believed to associate with catalytic subunits EXOSC10, and DIS3 or DIS3L in cytoplasmic- and nuclear-specific RNA exosome complex forms. Exo-9 is formed by a hexameric ring of RNase PH domain-containing subunits specifically containing the heterodimers EXOSC4-EXOSC9, EXOSC5-EXOSC8 and EXOSC6-EXOSC7, and peripheral S1 domain-containing components EXOSC1, EXOSC2 and EXOSC3 located on the

Subcellular Location:
Cytoplasm, Nucleus and Nucleolus.

Similarity:
Belongs to the RNase PH family.

SWISS:
Q96B26

Gene ID:
11340

Database links:

Entrez Gene: 11340 Human

Entrez Gene: 69639 Mouse

Omim: 606019 Human

SwissProt: Q96B26 Human

SwissProt: Q9D753 Mouse

Unigene: 294041 Human

Unigene: 29253 Mouse

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