Rabbit Anti-Exportin 4 antibody

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Exp4; Exportin-4; exportin4; FLJ13046; KIAA1721; xpo4; XPO4_HUMAN.

Cat:

SL14672R

Species Reactivity：

(predicted: Human,Mouse,Rat,Dog,Cow,Horse,)

Immunogen：

KLH conjugated synthetic peptide derived from human Exportin 4:101-200/1151

Format：

Liquid

Storage instructions：

Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ELISA=1:5000-10000IHC-P=1:100-500IHC-F=1:100-500ICC=1:100-500IF=1:100-500（Paraffin sections need to do antigen repair）not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

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Unit:

Price: $228.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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XPO4 belongs to a large family of karyopherins (see MIM 602738) that mediate the transport of proteins and other cargo between the nuclear and cytoplasmic compartments (Lipowsky et al., 2000 [PubMed 10944119]).[supplied by OMIM, Mar 2009]

Function:
Mediates the nuclear export of proteins (cargos) with broad substrate specificity. In the nucleus binds cooperatively to its cargo and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. XPO4 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.

Subcellular Location:
Cytoplasm. Nucleus. Shuttles between the nucleus and the cytoplasm.

Similarity:
Belongs to the exportin family.

SWISS:
Q9C0E2

Gene ID:
64328

Database links:

Entrez Gene: 64328 Human

Entrez Gene: 57258 Mouse

Entrez Gene: 290280 Rat

Omim: 611449 Human

SwissProt: Q9C0E2 Human

SwissProt: Q9ESJ0 Mouse

SwissProt: D3ZQI6 Rat

Unigene: 725169 Human

Unigene: 202747 Mouse

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