Rabbit Anti-FAM125A antibody

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CFBP; CIN85/CD2AP family-binding protein; ESCRT-I complex subunit MVB12A; F125A_HUMAN; FAM125A; Family with sequence similarity 125, member A; Multivesicular body subunit 12A; Protein FAM125A.

Cat:

SL14713R

Species Reactivity：

(predicted: Human,Mouse,Rat,Dog,Cow,Sheep,)

Immunogen：

KLH conjugated synthetic peptide derived from human FAM125A:131-230/273

Format：

Liquid

Storage instructions：

Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ELISA=1:5000-10000IHC-P=1:100-500IHC-F=1:100-500ICC=1:100-500IF=1:100-500（Paraffin sections need to do antigen repair）not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

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Unit:

Price: $228.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in the ligand-mediated internalization and down-regulation of EGF receptor.

Subcellular Location:
Cytoplasm. Nucleus. Endosome. Cytoplasm > cytoskeleton > centrosome. Late endosome membrane. Colocalizes with F-actin. Some fraction may be nuclear.

Tissue Specificity:
Ubiquitously expressed except in skeletal muscle.

Post-translational modifications:
Phosphorylated on Tyr-204 upon EGF stimulation. Phosphorylation is required for interaction with CD2AP and CIN85/SH3KBP1.

Similarity:
Belongs to the FAM125 family.
Contains 1 MABP domain.
Contains 1 UMA domain.

SWISS:
Q96EY5

Gene ID:
93343

Database links:

Entrez Gene: 93343 Human

SwissProt: Q96EY5 Human

Unigene: 515243 Human

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