TMEM157 is 190 amino acid protein encoded by a gene mapping to human chromosome 5. With 181 million base pairs encoding around 1,000 genes, chromosome 5 is about 6% of human genomic DNA. It is associated with Cockayne syndrome through the ERCC8 gene and familial adenomatous polyposis through the adenomatous polyposis coli (APC) tumor suppressor gene. Treacher Collins syndrome is also chromosome 5 associated and is caused by insertions or deletions within the TCOF1 gene. Deletion of the p arm of chromosome 5 leads to Cri du chat syndrome. Deletion of 5q or chromosome 5 altogether is common in therapy-related acute myelogenous leukemias and myelodysplastic syndrome.
Subcellular Location:
Membrane.
Similarity:
Belongs to the FAM174 family.
SWISS:
Q8TBP5
Gene ID:
345757
Database links:
Entrez Gene: 345757 Human
SwissProt: Q8TBP5 Human
Unigene: 75805 Human
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