Rabbit Anti-FAM18B antibody

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CGI 148; F18B1_HUMAN; Fam18b1; Family with sequence similarity 18, member B; Hypothetical protein LOC51030; Hypothetical protein LOC67510; NPD008; Ortholog of human family with sequence similarity 18 member B FAM18B; Protein FAM18B1; RP23 428I5.3

Cat:

SL14768R

Species Reactivity：

Zebrafish,(predicted: Human,Mouse,Rat,Dog,Pig,Cow,Rabbit,Sheep,)

Immunogen：

KLH conjugated synthetic peptide derived from human FAM18B:51-150/205

Format：

Liquid

Storage instructions：

Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ELISA=1:5000-10000IHC-P=1:100-500IHC-F=1:100-500ICC=1:100-500IF=1:100-500（Paraffin sections need to do antigen repair）not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

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Unit:

Price: $228.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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FAM18B2 is a 276 amino acid multi-pass membrane protein that exists as two alternatively spliced isoforms. The gene encoding FAM18B2 maps to human chromosome 17, which makes up over 2.5% of the human genome with about 81 million bases encoding over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Tumor suppressor p53 is necessary for maintenance of cellular genetic integrity by moderating cell fate through DNA repair versus cell death. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome. Like p53, BRCA1 is directly involved in DNA repair, though specifically it is recognized as a genetic determinant of early onset breast cancer and predisposition to cancers of the ovary, colon, prostate gland and fallopian tubes. Chromosome 17 is also linked to neurofibromatosis, a condition characterized by neural and epidermal lesions, and dysregulated Schwann cell growth. Alexander disease, Birt-Hogg-Dube syndrome and Canavan disease are also associated with chromosome 17.

Subcellular Location:
Membrane.

Similarity:
Belongs to the FAM18/TVP23 family.

SWISS:
Q9NYZ1

Gene ID:
51030

Database links:

Entrez Gene: 51030 Human

SwissProt: Q9NYZ1 Human

Unigene: 87295 Human

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