Component of the WASH complex, a complex present at the surface of endosomes that recruits and activates the Arp2/3 complex to induce actin polymerization. The WASH complex plays a key role in the fission of tubules that serve as transport intermediates during endosome sorting. In the complex, it probably mediates the recruitment of the complex to endosome membranes. Plays a role in fluid-phase endocytosis, a process exploited by vaccinia intracellular mature virus (IMV) to enter cells. As a result, may facilitate the penetration of IMV into cells.
Subcellular Location:
Early endosome membrane. Cell membrane. Partially colocalizes with RAB11A, a recycling endosome marker. Associates with lipid raft microdomains on the plasma membrane.
Similarity:
Belongs to the FAM21 family.
SWISS:
Q9Y4E1
Gene ID:
253725
Database links:
Entrez Gene: 253725 Human
SwissProt: Q9Y4E1 Human
Unigene: 365286 Human
Unigene: 449662 Human
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