Making up nearly 6% of the human genome, chromosome 6 contains around 1,200 genes within 170 million base pairs of sequence. Deletion of a portion of the q arm of chromosome 6 is associated with early onset intestinal cancer suggesting the presence of a cancer susceptibility locus. Porphyria cutanea tarda is associated with chromosome 6 through the HFE gene which, when mutated, predisposes an individual to developing this porphyria. Notably, the PARK2 gene, which is associated with Parkinson's disease, and the genes encoding the major histocompatiblity complex proteins, which are key molecular components of the immune system and determine predisposition to rheumatic diseases, are also located on chromosome 6. Stickler syndrome, 21-hydroxylase deficiency and maple syrup urine disease are also associated with genes on chromosome 6. A bipolar disorder susceptibility locus has been identified on the q arm of chromosome 6. The FAM46A gene product has been provisionally designated FAM46A pending further characterization.
Tissue Specificity:
Widely expressed, with preferential expression observed in the retina compared to other ocular tissues.
Similarity:
Belongs to the FAM46 family.
SWISS:
Q96IP4
Gene ID:
55603
Database links:
Entrez Gene: 55603 Human
Entrez Gene: 212943 Mouse
Omim: 611357 Human
SwissProt: Q96IP4 Human
Unigene: 10784 Human
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