With approximately 135 million base pairs and 1,400 genes, chromosome 11 makes up around 4% of human genomic DNA and is considered a gene and disease association dense chromosome. The chromosome 11 encoded Atm gene is important for regulation of cell cycle arrest and apoptosis following double strand DNA breaks. Atm mutation leads to the disorder known as ataxia-telangiectasia. The blood disorders Sickle cell anemia and ∫ thalassemia are caused by HBB gene mutations. Wilms' tumors, WAGR syndrome and Denys-Drash syndrome are associated with mutations of the WT1 gene. Jervell and Lange-Nielsen syndrome, Jacobsen syndrome, Niemann-Pick disease, hereditary angioedema and Smith-Lemli-Opitz syndrome are also associated with defects in chromosome 11. The FAM55A gene product has been provisionally designated FAM55A pending further characterization.
Subcellular Location:
Secreted.
Similarity:
Belongs to the FAM55 family.
SWISS:
Q8N323
Gene ID:
120400
Database links:
Entrez Gene: 120400 Human
SwissProt: Q8N323 Human
Unigene: 721328 Human
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