Rabbit Anti-Fascin 2 antibody

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Fascin homolog 2, actin bundling protein, retinal Strongylocentrotus purpuratus; Fascin Strongylocentrotus purpuratus homolog 2 actin bundling protein, retinal; Fascin-2; FSCN2; FSCN2_HUMAN; Retinal fascin; RFSN; RP30.

Cat:

SL16028R

Species Reactivity：

(predicted: Human,Mouse,Rat,Dog,Pig,Cow,Rabbit,)

Immunogen：

KLH conjugated synthetic peptide derived from human Fascin 2:151-250/492

Format：

Liquid

Storage instructions：

Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ELISA=1:5000-10000IHC-P=1:100-500IHC-F=1:100-500ICC=1:100-500IF=1:100-500（Paraffin sections need to do antigen repair）not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

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Unit:

Price: $228.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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This gene encodes a member of the fascin protein family. Fascins crosslink actin into filamentous bundles within dynamic cell extensions. This family member is proposed to play a role in photoreceptor disk morphogenesis. A mutation in this gene results in one form of autosomal dominant retinitis pigmentosa and macular degeneration. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Function:
Acts as an actin bundling protein. May play a pivotal role in photoreceptor cell-specific events, such as disk morphogenesis.

Subcellular Location:
Cytoplasm > cytoskeleton. Cell projection > stereocilium.

Tissue Specificity:
Localized specifically in the outer and inner segments of the photoreceptor cells in the retina.

DISEASE:
Defects in FSCN2 are the cause of retinitis pigmentosa type 30 (RP30) [MIM:607921]. RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. RP30 inheritance is autosomal dominant.

Similarity:
Belongs to the fascin family.

SWISS:
O14926

Gene ID:
25794

Database links:

Entrez Gene: 25794 Human

Entrez Gene: 337926 Cow

Entrez Gene: 483362 Dog

Entrez Gene: 47621 Mouse

Entrez Gene: 303741 Rat

Omim: 607643 Human

SwissProt: O18728 Cow

SwissProt: O14926 Human

SwissProt: Q32M02 Mouse

Unigene: 118555 Human

Unigene: 375010 Mouse

Unigene: 481403 Mouse

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