This gene encodes a member of the F-box protein family which is characterized by the F-box motif. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and it contains an F-box domain. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Function:
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Able to recognize and bind denatured glycoproteins, which are modified with complex-type oligosaccharides. Also recognizes sulfated glycans. Does not bind high-mannose glycoproteins.
Tissue Specificity:
Expressed in heart, skeletal muscle, liver and kidney. Expressed at lower levels in spleen and brain.
Similarity:
Contains 1 F-box domain.
Contains 1 FBA (F-box associated) domain.
SWISS:
Q96EF6
Gene ID:
115290
Database links:
Entrez Gene: 115290 Human
Entrez Gene: 50760 Mouse
Entrez Gene: 292757 Rat
GenBank: NM_024907 Human
GenBank: NM_148169 Human
GenBank: NM_015796 Mouse
Omim: 609094 Human
SwissProt: Q96EF6 Human
SwissProt: Q9QZM8 Mouse
SwissProt: Q6AY27 Rat
Unigene: 531770 Human
Unigene: 358659 Mouse
Unigene: 5726 Rat
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