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Rabbit Anti-FBLIM1 antibody
This gene encodes a protein with an N-terminal filamin-binding domain, a central proline-rich domain, and, multiple SLCterminal LIM domains. This protein localizes at cell junctions and may link cell adhesion structures to the actin cytoskeleton. This protein may be involved in the assembly and stabilization of actin-filaments and likely plays a role in modulating cell adhesion, cell morphology and cell motility. This protein also localizes to the nucleus and may affect cardiomyocyte differentiation after binding with the CSX/NKX2-5 transcription factor. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Function:
Serves as an anchoring site for cell-ECM adhesion proteins and filamin-containing actin filaments. Is implicated in cell shape modulation (spreading) and motility. May participate in the regulation of filamin-mediated cross-linking and stabilization of actin filaments. May also regulate the assembly of filamin-containing signaling complexes that control actin assembly.
Subcellular Location:
Cytoplasm > cell cortex. Cell junction > focal adhesion. Cytoplasm > cytoskeleton. Associated with actin stress fiber at cell-ECM focal adhesion sites. Isoform 1 and isoform 3 are recruited and localized at actin stress fibers and clustered at cell-EMC adhesion sites through interaction with PLEKHC1. Isoform 2 is localized at actin stress fibers.
Tissue Specificity:
Isoform 1 and isoform 3 are expressed in heart, kidney, lung, pancreas, placenta and platelets. Isoform 2 is expressed in brain, heart, kidney, lung, pancreas, placenta, skeletal muscle and platelets.
Similarity:
Contains 3 LIM zinc-binding domains.
SWISS:
Q8WUP2
Gene ID:
54751
Database links:
Entrez Gene: 54751 Human
Entrez Gene: 767833 Cow
Entrez Gene: 74202 Mouse
Omim: 607747 Human
SwissProt: Q1JQB5 Cow
SwissProt: Q8WUP2 Human
SwissProt: Q71FD7 Mouse
Unigene: 530101 Human
Unigene: 286536 Mouse
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