Involved in pre-rRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in pre-ribosomal RNA.
Function:
S-adenosyl-L-methionine-dependent methyltransferase that has the ability to methylate both RNAs and proteins. Involved in pre-rRNA processing by catalyzing the site-specific 2'-hydroxyl methylation of ribose moieties in pre-ribosomal RNA. Also acts as a protein methyltransferase by mediating methylation of glutamine residues (By similarity).
Subcellular Location:
Nuclear, nucleolus. Note=Fibrillar region of the nucleolus (By similarity).
Post-translational modifications:
By homology to other fibrillarins, some or all of the N-terminal domain arginines are modified to asymmetric dimethylarginine (DMA).
Similarity:
Belongs to the methyltransferase superfamily. Fibrillarin family.
SWISS:
A6NHQ2
Gene ID:
345630
Database links:
Entrez Gene: 345630 Human
Entrez Gene: 237730 Mouse
SwissProt: A6NHQ2 Human
SwissProt: Q80WS3 Mouse
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