This gene encodes a member of the F-box protein family which is characterized by a 42-48 amino acid motif, the F-box, which binds to the S-phase kinase-associated protein 1 (Skp1) protein. The F-box proteins constitute one of the four subunits of E3 ubiquitin protein ligases called SCFs (SKP1-Cul1-F-box), which play a role in phosphorylation-dependent ubiquitination of proteins. The F-box proteins are divided into 3 subfamilies based on the other domain in the protein: F-box proteins that also have a WD-40 domain (Fbws subfamily), F-box proteins that also have leucine-rich repeats (Fbls subfamily) and F-box proteins that contain other motifs or lack known protein-interaction domains (Fbxs subfamily). The protein encoded by this gene belongs to the Fbls subfamily. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013]
Function:
Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation.
Similarity:
Contains 1 F-box domain.
Contains 11 LRR (leucine-rich) repeats.
SWISS:
Q9UJT9
Gene ID:
23194
Database links:
Entrez Gene: 23194 Human
Entrez Gene: 448987 Mouse
Omim: 605656 Human
SwissProt: Q9UJT9 Human
SwissProt: Q5BJ29 Mouse
Unigene: 433057 Human
Unigene: 76798 Human
Unigene: 253378 Mouse
|
|
