This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbx class. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
Function:
FBXO16 is a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. FBXO16 probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. It is expressed in heart, spleen and colon.
Subunit:
Part of a SCF (SKP1-cullin-F-box) protein ligase complex (By similarity).
Tissue Specificity:
Expressed in heart, spleen and colon.
Similarity:
Contains 1 F-box domain.
SWISS:
Q8IX29
Gene ID:
157574
Database links:
Entrez Gene: 157574 Human
Entrez Gene: 50759 Mouse
Entrez Gene: 305970 Rat
Omim: 608519 Human
SwissProt: Q8IX29 Human
SwissProt: Q9QZM9 Mouse
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