This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. It contains a SLCterminal amino acid sequence that bears a significant similarity with a portion of yeast Sec7p, a critical regulator of vesicular protein transport. This human protein may interact with ADP-ribosylation factor(s)(ARFs) and exhibit ARF-GEF (guanine nucleotide exchange factor) activity. [provided by RefSeq, Jul 2008]
Function:
May promote guanine-nucleotide exchange on an ARF. Promotes the activation of ARF through replacement of GDP with GTP.
Similarity:
Contains 1 F-box domain.
Contains 1 SEC7 domain.
SWISS:
Q9NRD0
Gene ID:
26269
Database links:
Entrez Gene: 26269 Human
Entrez Gene: 50753 Mouse
Entrez Gene: 306436 Rat
Omim: 605649 Human
SwissProt: Q5E9G6 Cow
SwissProt: Q9NRD0 Human
SwissProt: Q9QZN3 Mouse
Unigene: 76917 Human
Unigene: 251174 Mouse
Unigene: 91689 Rat
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