Fc (Ig constant fragment) receptors ensure protection of the host against foreign antigens, such as microorganisms and pathogens, by removing Ig-coated antigen complexes from circulation. Fc receptors are present on lymphoid and myeloid derivatives, where they mediate endocytosis of Ig-antigen complexes, antibody production in B cells through T cell antigen presentation, cytotoxicity and the release of cytokines and reactive oxygen species. The Fc α/μ receptor (FCAMR) functions as a receptor for the Fc fragment of IgA and IgM and mediates their endocytosis. FCAMR is a 532 amino acid protein that is expressed in mesangial cells and is upregulated by IFNG/IFN-γ. It is also expressed in secondary lymphoid organs, such as lymph node and appendix, kidney and intestine, suggesting an important role of the receptor for immunity in these organs.
Function:
Functions as a receptor for the Fc fragment of IgA and IgM. Binds IgA and IgM with high affinity and mediates their endocytosis. May function in the immune response to microbes mediated by IgA and IgM.
Subcellular Location:
Cell membrane.
Tissue Specificity:
Expressed by mesangial cells.
Post-translational modifications:
N-glycosylated.
Similarity:
Contains 1 Ig-like SLVtype (immunoglobulin-like) domain.
SWISS:
Q8WWV6
Gene ID:
83953
Database links:
Entrez Gene: 83953 Human
Omim: 605484 Human
SwissProt: Q8WWV6 Human
Unigene: 145519 Human
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