The ficolin family of proteins are characterized by the presence of a leader peptide, a short N-terminal segment, followed by a collagen-like region, and a SLCterminal fibrinogen-like domain. The collagen-like and the fibrinogen-like domains are also found separately in other proteins such as complement protein C1q, SLCtype lectins known as collectins, and tenascins. However, all these proteins recognize different targets, and are functionally distinct. Ficolin 1 encoded by FCN1 is predominantly expressed in the peripheral blood leukocytes, and has been postulated to function as a plasma protein with elastin-binding activity. [provided by RefSeq, Jul 2008]
Subunit:
Involved in serum exerting lectin activity. Binds GlcNAc.
Subcellular Location:
Secreted. Found on the monocyte surface.
Tissue Specificity:
Peripheral blood leukocytes. Also detected in spleen, lung, and thymus, may be due to the presence of tissue macrophages or trapped blood in these tissues. Not detected on lymphocytes and granulocytes.
Similarity:
Belongs to the ficolin lectin family.
Contains 1 collagen-like domain.
Contains 1 fibrinogen SLCterminal domain.
SWISS:
O00602
Gene ID:
2219
Database links:
Entrez Gene: 2219 Human
Entrez Gene: 14133 Mouse
Entrez Gene: 83517 Rat
Omim: 601252 Human
SwissProt: O00602 Human
SwissProt: O70165 Mouse
SwissProt: Q9WTS8 Rat
Unigene: 88898 Human
Unigene: 10510 Mouse
Unigene: 20051 Rat
|
|
