This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein contains three extracellular C2-like immunoglobulin domains, a transmembrane domain and a cytoplasmic domain with two immunoreceptor-tyrosine activation motifs. This protein may play a role in the regulation of cancer cell growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]
Function:
May function as an activating coreceptor in B-cells. May function in B-cells activation and differentiation.
Subcellular Location:
Cell membrane; Single-pass type I membrane protein.
Tissue Specificity:
Primarily expressed in secondary lymphoid tissues by mature subsets of B-cells. Detected in spleen, lymph node, heart, skeletal muscle, kidney, liver and placenta. Specifically expressed by mature B lineage cells with higher expression in naive versus memory B-cells (at protein level).
Post-translational modifications:
Phosphorylated on tyrosines upon activation.
Similarity:
Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
SWISS:
Q96LA6
Gene ID:
115350
Database links:
Entrez Gene: 115350 Human
Omim: 606508 Human
SwissProt: Q96LA6 Human
Unigene: 656112 Human
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