This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein has four extracellular C2-type immunoglobulin domains, a transmembrane domain and a cytoplasmic domain that contains three immune-receptor tyrosine-based inhibitory motifs. This protein may play a role in the function of memory B-cells in the epithelia. Aberrations in the chromosomal region encoding this gene are associated with non-Hodgkin lymphoma and multiple myeloma. [provided by RefSeq, Apr 2009]
Function:
May function as an inhibitor of the B-cell receptor signaling. May function in the B-cell-mediated immune response.
Subcellular Location:
Cell membrane.
Tissue Specificity:
Specifically expressed by memory and monocytoid B-cells which populate spleen and lymph nodes. Preferentially expressed in memory B-cells associated with mucosal tissue (at protein level).
Post-translational modifications:
Phosphorylated on cytoplasmic tyrosines upon activation
DISEASE:
Note=A chromosomal aberration involving FCRL4 is found in non-Hodgkin lymphoma (NHG). Translocation t(1;1)(p36.3; q21.1-2).
Note=A chromosomal aberration involving FCRL4 is found in multiple myeloma (MM). Translocation t(1;14)(q21;q32) that forms a FCRL4-IGHA1 fusion protein.
Similarity:
Contains 4 Ig-like C2-type (immunoglobulin-like) domains.
SWISS:
Q96PJ5
Gene ID:
83417
Database links:
Entrez Gene: 83417 Human
Omim: 605876 Human
SwissProt: Q96PJ5 Human
Unigene: 120260 Human
|
|
