The Fc receptor homolog (FcRH) family of proteins are related to the classical Fc receptors (FcR) and belong to the immunoglobulin receptor superfamily. The proteins in the FcRH family are type I transmembrane glycoproteins and consist of FcRH1-FcRH6. The genes encoding the human FcRH proteins map to chromosome 1, near the related FCR genes. The FcRH proteins, which are involved in immune system regulation, have immunoreceptor-tyrosine inhibitory motifs in their cytoplasmic domains. Mutations in the gene encoding for the FcRH proteins may be associated with systemic lupus erythematosus, autoimmune thyroid disease and rheumatoid arthritis. The FcRH genes are expressed primarily, although not exclusively, by mature B lineage cells, and may serve important regulatory roles in normal and neoplastic B cell development.
Subunit:
Interacts with PTPN11.
Subcellular Location:
Membrane.
Tissue Specificity:
Expressed by cytolytic cells including NK cells, effector and effector-memory CD8+ T-cells. Expression among T-cells is greatly expanded in HISLV1 infected individuals, and includes not only effector and effector-memory CD8+ T-cells but also populations of CD4+ T-cells.
Post-translational modifications:
Phosphorylated on Tyr residue, inducing association with PTPN11.
Similarity:
Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
SWISS:
Q6DN72
Gene ID:
343413
Database links:
Entrez Gene: 343413 Human
Omim: 613562 Human
SwissProt: Q6DN72 Human
Unigene: 196955 Human
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