FCRL2 belongs to the Fc receptor family. Fc receptors are involved in phagocytosis, antibody-dependent cell cytotoxicity, immediate hypersensitivity, and transcytosis of immunoglobulins via their ability to bind immunoglobulin (Ig) constant regions (Chikaev et al., 2005 [PubMed 15676285]).[supplied by OMIM, Mar 2008]
Function:
FCRLB belongs to the Fc receptor family. Fc receptors are involved in phagocytosis, antibody-dependent cell cytotoxicity, immediate hypersensitivity, and transcytosis of immunoglobulins via their ability to bind immunoglobulin (Ig) constant regions.
Subcellular Location:
Cytoplasm. Endoplasmic reticulum. Note: Seems not to be secreted.
Tissue Specificity:
Expressed at low levels. Expressed in B-lymphocytes. Detected in tonsil, lung, kidney, spleen and placenta. Expressed by a small subset of germinal center B-cells in tonsils and by melanocytes (at protein level).
Similarity:
Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
SWISS:
Q6BAA4
Gene ID:
127943
Database links:
Entrez Gene: 127943 Human
Omim: 609251 Human
SwissProt: Q6BAA4 Human
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