FGD6 is a 1,430 amino acid cytoplasmic protein that belongs to the FGD family and exists as two alternatively spliced isoforms. Thought to activate Cdc42 by exchanging bound GDP for free GTP, FGD6 is also implicated in maintenance of the actin cytoskeleton and regulating cell shape. Encoded by a gene that maps to human chromosome 12q22, FGD6 contains one FYVE-type zinc finger, two PH domains and a single DH (DBL-homology) domain.
Function:
FGD6 may activate CDC42 by exchanging bound GDP for free GTP. It may also play a role in regulating the actin cytoskeleton and cell shape. There are two isoforms.
Subcellular Location:
Cytoplasm (Probable). Cytoplasm, cytoskeleton (Probable).
SWISS:
Q6ZV73
Gene ID:
55785
Database links:
Entrez Gene: 55785 Human
SwissProt: Q6ZV73 Human
Unigene: 506381 Human
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