The protein encoded by this gene is a member of a family of proteins containing a four-and-a-half LIM domain, which is a highly conserved double zinc finger motif. The encoded protein has been shown to interact with the cancer developmental regulators SMAD2, SMAD3, and SMAD4, the skeletal muscle myogenesis protein MyoD, and the high-affinity IgE beta chain regulator MZF-1. This protein may be involved in tumor suppression, repression of MyoD expression, and repression of IgE receptor expression. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
Tissue Specificity:
Expressed only in skeletal muscle.
Similarity:
Contains 4 LIM zinc-binding domains.
SWISS:
Q13643
Gene ID:
2275
Database links:
Entrez Gene: 2275 Human
Entrez Gene: 14201 Mouse
Entrez Gene: 396986 Pig
Entrez Gene: 313582 Rat
Omim: 602790 Human
SwissProt: Q3ZBI6 Cow
SwissProt: Q13643 Human
SwissProt: Q9R059 Mouse
Unigene: 57687 Human
Unigene: 331856 Mouse
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