Acidic fibroblast growth factor is mitogenic for a variety of different cell types and acts by stimulating mitogenesis or inducing morphological changes and differentiation. The FIBP protein is an intracellular protein that binds selectively to acidic fibroblast growth factor (aFGF). It is postulated that FIBP may be involved in the mitogenic action of aFGF. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Function:
May be involved in mitogenic function of FGF1.
Subcellular Location:
Nucleus. Endomembrane system. Also associated with cytoplasmic membranes, particularly of mitochondria.
Tissue Specificity:
Highly expressed in heart, skeletal muscle and pancreas. Expressed at lower levels in brain. Also found in placenta, liver and kidney.
SWISS:
O43427
Gene ID:
9158
Database links:
Entrez Gene: 9158 Human
Entrez Gene: 58249 Mouse
Omim: 608296 Human
SwissProt: O43427 Human
SwissProt: Q9JI19 Mouse
Unigene: 7768 Human
Unigene: 329656 Mouse
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