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Rabbit Anti-FLJ14213 antibody
mTOR is a large protein kinase that is important in cell growth and functions as the mammalian target of Rapamycin, an immunosuppressant that blocks vessel restenosis and also has potential anticancer applications. Rapamycin-insensitive companion of mTOR, also designated Rictor, forms a complex (designated mTORC2) with mTOR that directly phosphorylates Akt/PKB on Ser473 and plays a key role in growth signaling pathways. Protor-2, also known as PROTOR2 or FLJ14213, is a 368 amino acid protein that is thought to interact with the mTORC2 complex and, via this interaction, may regulate organization of the Actin cytoskeleton. Three isoforms of Protor-2 are expressed due to alternative splicing events.
Function:
May be part of the TORC2 complex which plays a critical role in AKT1 'Ser-473' phosphorylation, and may modulate the phosphorylation of PKCA and regulate actin cytoskeleton organization.
Subunit:
Interacts with the mammalian target of rapamycin complex 2 (mTORC2) which contains MTOR, MLST8, PRR5, RICTOR, MAPKAP1 and DEPTOR. Interacts with RFFL.
Post-translational modifications:
Ubiquitinated. Ubiquitination by RFFL promotes proteasomal degradation of PRR5L thereby modifying the substrate-specific activity of the mTORC2 complex. Ubiquitination by RFFL is stimulated by LPA/lysophosphatidic acid.
Similarity:
Belongs to the PROTOR family.
SWISS:
Q6MZQ0
Gene ID:
79899
Database links:
Entrez Gene: 79899 Human
Entrez Gene: 505048 Cow
Entrez Gene: 72446 Mouse
Entrez Gene: 362171 Rat
Omim: 611728 Human
SwissProt: Q6MZQ0 Human
SwissProt: A2AVJ5 Mouse
SwissProt: A1L1K1 Rat
Unigene: 19987 Human
Unigene: 24138 Mouse
Unigene: 19060 Rat
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