Rabbit Anti-FLJ20530/C8orf52 antibody

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C8orf52; Chromosome 8 open reading frame 52; FLJ20530; INT8; Integrator complex subunit 8; INTS 8; INT8_HUMAN ； INTS8; KAONASHI protein 1; KAONASHI1; MGC131633.

Cat:

SL16110R

Species Reactivity：

(predicted: Human,Mouse,Rat,Dog,Pig,Cow,Horse,Rabbit,Sheep,)

Immunogen：

KLH conjugated synthetic peptide derived from human FLJ20530/C8orf52:651-750/995

Format：

Liquid

Storage instructions：

Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

WB=1:500-2000ELISA=1:5000-10000IHC-P=1:100-500IHC-F=1:100-500ICC=1:100-500IF=1:100-500（Paraffin sections need to do antigen repair）not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

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Unit:

Price: $228.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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This gene encodes a subunit of the Integrator complex which is involved in the cleavage of small nuclear RNAs U1 and U2 within the nucleus. The encoded protein associates with RNA polymerase II and is recruited to the U1 and U2 small nuclear RNA genes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]

Function:
FLJ20530 is a component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3' box-dependent processing. The Integrator complex is associated with the SLCterminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes.

Subunit:
Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, CPSF3L/INTS11 and INTS12.

Subcellular Location:
Nuclear

Similarity:
Contains 4 TPR repeats.

SWISS:
Q75QN2

Gene ID:
55656

Database links:

Entrez Gene: 55656 Human

Entrez Gene: 72656 Mouse

Omim: 611351 Human

SwissProt: Q75QN2 Human

SwissProt: Q80V86 Mouse

Unigene: 521693 Human

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