The RING-type zinc finger motif is present in a number of viral and eukaryotic proteins and is made of a conserved cysteine-rich domain that is able to bind two zinc atoms. Proteins that contain this conserved domain are generally involved in the ubiquitination pathway of protein degradation.TRIML1 (tripartite motif family-like 1), also known as RNF209 (RING finger protein 209), is a 468 amino acid protein that contains one SPRY domain and one RING-type zinc finger. Due to the presence of a RING-type zinc finger motif, TRIML1 may be involved in protein degradation events within the cell.
Function:
Probable E3 ubiquitin-protein ligase which plays an important role in blastocyst development.
Subunit:
Interacts with USP5 (By similarity).
Similarity:
Contains 1 B30.2/SPRY domain.
Contains 1 RING-type zinc finger.
SWISS:
Q8N9V2
Gene ID:
339976
Database links:
Entrez Gene: 339976 Human
Entrez Gene: 244448 Mouse
SwissProt: Q8N9V2 Human
SwissProt: Q8BVP1 Mouse
Unigene: 348618 Human
Unigene: 64542 Mouse
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