This gene encodes a formin-related protein. Formin-related proteins have been implicated in morphogenesis, cytokinesis, and cell polarity. Alternatively spliced transcript variants encoding different isoforms have been described but their full-length nature has yet to be determined. [provided by RefSeq, Jul 2008]
Function:
This gene encodes a formin-related protein. Formin-related proteins have been implicated in morphogenesis, cytokinesis, and cell polarity. Alternatively spliced transcript variants encoding different isoforms have been described but their full-length nature has yet to be determined.
Subunit:
Self-associates via the FH2 domain. Binds to F-actin via its N-terminus. Binds to the cytoplasmic domain of CD21 via its SLCterminus. Interacts with ROCK1 in a Src-dependent manner.
Subcellular Location:
Cytoplasm. Cytoplasm, cytoskeleton. Cell projection, bleb. Note=Predominantly cytoplasmic.
Tissue Specificity:
Ubiquitous. Highly expressed in spleen.
Post-translational modifications:
Phosphorylated by ROCK1.
Similarity:
Belongs to the formin homology family.
Contains 1 DAD (diaphanous autoregulatory) domain.
Contains 1 FH1 (formin homology 1) domain.
Contains 1 FH2 (formin homology 2) domain.
Contains 1 GBD/FH3 (Rho GTPase-binding/formin homology 3) domain.
SWISS:
Q96PY5
Gene ID:
114793
Database links:
Entrez Gene: 114793 Human
Entrez Gene: 71409 Mouse
Entrez Gene: 311033 Rat
SwissProt: Q96PY5 Human
SwissProt: A2APV2 Mouse
Unigene: 654630 Human
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