Metabolic N-oxidation of the diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man resulting in a small subpopulation with reduced TMA N-oxidation capacity resulting in fish odor syndrome Trimethylaminuria. Three forms of the enzyme, FMO1 found in fetal liver, FMO2 found in adult liver, and FMO3 are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]
Function:
This protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides. Form I catalyzes the N-oxygenation of secondary and tertiary amines.
Subcellular Location:
Microsome membrane. Endoplasmic reticulum membrane.
Tissue Specificity:
Expressed mainly in fetal liver, adult kidney and, to a lesser extent, the intestine.
Similarity:
Belongs to the FMO family.
SWISS:
Q01740
Gene ID:
2326
Database links:
Entrez Gene: 2326 Human
Entrez Gene: 14261 Mouse
Entrez Gene: 25256 Rat
Omim: 136130 Human
SwissProt: Q01740 Human
SwissProt: P50285 Mouse
SwissProt: P36365 Rat
Unigene: 1424 Human
Unigene: 976 Mouse
Unigene: 867 Rat
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