FNBP4 is a 1,017 amino acid protein that contains two WW domains and binds to the Arg/Gly-rich-flanked Pro-rich domains of Formin 1, possibly regulating Formin 1 function. In response to DNA damage, FNBP4 is subject to post-translational phosphorylation, probably by ATM or ATR. The gene encoding FNBP4 maps to human chromosome 11, which houses over 1,400 genes and comprises nearly 4% of the human genome. Jervell and Lange-Nielsen syndrome, Jacobsen syndrome, Niemann-Pick disease, hereditary angioedema and Smith-Lemli-Opitz syndrome are associated with defects in genes that maps to chromosome 11.
Function:
FNBP4 (Formin binding protein 4) binds FMN1. It contains 2 WW domains which interact with the Arg/Gly-rich-flanked Pro-rich domains of KHDRBS1/SAM68. Arginine methylation in these regions has no effect on this binding.
Similarity:
Contains 2 WW domains.
SWISS:
Q8N3X1
Gene ID:
2372
Database links:
Entrez Gene: 2372 Human
Entrez Gene: 55935 Mouse
Entrez Gene: 311183 Rat
SwissProt: Q8N3X1 Human
SwissProt: Q6ZQ03 Mouse
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