Members of the winged-helix/forkhead family of transcription factors, such as FOXN4, are characterized by a 110-amino acid DNA-binding domain that can fold into a variant of the helix-turn-helix motif consisting of 3 alpha helices flanked by 2 large loops or wings. These transcription factors are involved in a variety of biologic processes as key regulators in development and metabolism (Li et al., 2004 [PubMed 15363391]).[supplied by OMIM, Mar 2008]
Subcellular Location:
Nucleus.
Similarity:
Contains 1 fork-head DNA-binding domain.
SWISS:
Q96NZ1
Gene ID:
121643
Database links:
Entrez Gene: 121643 Human
Omim: 609429 Human
SwissProt: Q96NZ1 Human
Unigene: 528316 Human
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