FRYL plays a key role in maintaining the integrity of polarized cell extensions during morphogenesis. It regulates the actin cytoskeleton and plays a key role in patterning sensory neuron dendritic fields by promoting avoidance between homologous dendrites as well as by limiting dendritic branching. FRYL May function as a transcriptional activator.
Function:
Plays a key role in maintaining the integrity of polarized cell extensions during morphogenesis, regulates the actin cytoskeleton and plays a key role in patterning sensory neuron dendritic fields by promoting avoidance between homologous dendrites as well as by limiting dendritic branching (By similarity). May function as a transcriptional activator.
Tissue Specificity:
Widely expressed with higher expression in colon, placenta, brain and cells of lymphoid origin.
DISEASE:
Note=A chromosomal aberration involving FRYL is found in treatment-related acute lymphoblastic leukemia (ALL). Translocation t(4;11)(p12;q23) that forms a KMT2A/MLL1-FRYL fusion protein.
Similarity:
Belongs to the furry protein family.
SWISS:
O94915
Gene ID:
285527
Database links:
Entrez Gene: 285527 Human
Entrez Gene: 72313 Mouse
SwissProt: O94915 Human
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