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Rabbit Anti-FRZB/FRP-3 antibody
The protein encoded by this gene is a secreted protein that is involved in the regulation of bone development. Defects in this gene are a cause of female-specific osteoarthritis (OA) susceptibility. [provided by RefSeq, Apr 2010]
Function:
SFRP3/FRZB appears to be involved in limb skeletogenesis by regulating chondrocyte maturation and long bone development. Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. Antagonist of Wnt8 signaling.
Subcellular Location:
Secreted
Tissue Specificity:
Expressed specifically in skeletal muscle. Not detected in heart.
Similarity:
Belongs to the myozenin family.
SWISS:
Q92765
Gene ID:
2487
Database links:
Entrez Gene: 2487 Human
Omim: 605083 Human
SwissProt: Q92765 Human
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